Drug delivery systems play a crucial role in the treatment and management of serious medical conditions. Microelectromechanical systems (MEMS) technologies have allowed the development of advanced miniaturized devices for medical and biological applications. However, flexible drug delivery systems (f-DDS) is difficult to achieve due to a brittle nature of devices. Our group have developed the flexible drug delivery microdevice (f-DDM) with controlled release based on innovative MEMS technology and inorganic lase lift-off (ILLO) technique. The f-DDM was conformally implanted on the cerebral cortex of live mice, and electrically triggered drug delivery to local tissue was successfully demonstrated. This technology can be integrated with micro-valves, micro-sensors, and CMOS IC-based microcontroller chip to achieve feedback control at a specific time, dosage, and location on curved surface inside human body.
"Flexible Wireless Powered Drug Delivery System for Targeted Administration on Cerebral Cortex", Nano Energy, 51, 102, 2018
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